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MOTS-c Vial

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Research suggests that MOTS-c is a mitochondrial peptide designed to help regulate metabolism and insulin action.|

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MOTS-c Peptide Vial {anme1}  Pharmagrade Store online

Research suggests MOTS-c is a mitochondrial peptide designed to regulate metabolism and insulin action [1]. It is an MDP (mitochondrial-derived peptide) encoded as an sORF (short open reading frames) in the mitochondrial 12S rRNA. MOTS-c has a range of biological functions such as stress response and metabolic regulation. MOT-c can translocate to the nucleolus to respond to metabolic stress.

A study for sORFs in the 12rRNA showed that there are 51 pairs that translate into a 16 amino acid peptide that can undergo putative translation modifications this is the MOTS-C (mitochondrial open reading frame of twelve S rRNA type c).

Cellular Metabolism Regulation

HEK293 cells treated with MOT-c were subjected to microarray analysis, the resulted showed that MOT-c is a biologically active peptide. A clear global gene expression profile shifted 72 hours after MOT-c treatment, this was showed by PCA (principal component analysis). Parametric analysis of gene [2] set enrichment showed that gene expression was altered significantly four hours after MOTS-c treatment and became more distinct after 72 hours.

Genes associated with cellular metabolism and inflammation showed a distinct expression after MOTS-c treatment. An examination of the effects of MOTS-c on cellular metabolism showed that 194 metabolites out of the 356 known metabolites altered significantly by MOTS-c ST cells, 49 of the metabolites were altered 24 hours after the MOTS-c ST treatment and 177 metabolites were altered after 72 hours. The pattern of the metabolites progressed with time with most biochemicals remaining consistently altered at both 24 and 72 hours.

There was an overlap between the metabolites altered in MOTS-c ST(stably expressing MOTS-c) and MOTS-c (exogenous synthetic MOTS-c) most of the metabolites altered in MOTS-c ST cells overlapped with those treated with MOTS-c for 72 hours. Metabolites involved in purine metabolism and dipeptide metabolism were constantly reduced while the metabolites involved acylcarnitine metabolism and methionine cycle were constantly increased.

Gene Expression

The research showed that the MOTS-c peptide can translocate into the nucleus to regulate nuclear gene expression. The AMPK [3] (adenosine monophosphate-activated protein kinase) is triggered by metabolic stress which causes the translocation of MOTS-c to the nucleus. MOTS-c helps then helps the nucleus with cellular stress/ metabolic stress resistance. Once in the nucleus, MOTS-c can combine with chromatin to regulate gene expression in the nucleus.

References

[1] https://www.sciencedirect.com/science/article/pii/S1550413118303905

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350682/

[3] https://www.researchgate.net/publication/273122087_The_Mitochondrial-Derived_Peptide_MOTS-c_Promotes_Metabolic_Homeostasis_and_Reduces_Obesity_and_Insulin_Resistance

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10mg

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